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Kick-off of the CRIMSON project for a next-generation microscope

18 Dec '20 | By Biophotonics.World
Kick-off of the CRIMSON project for a next-generation microscope
Optical Microscope CRIMSON Project
Image source: Politecnico di Milano

A breakthrough in microscopy and endoscopy will soon revolutionize the study of the cellular origin of diseases, advancing the field of precision medicine. This is the goal of CRIMSON, a trans-disciplinary and trans-national research project recently funded by European Commission. It will develop the next-generation bio-photonics imaging device for biomedical research, combining advanced laser techniques with artificial-intelligence data analysis. This groundbreaking microscope will provide three-dimensional quantitative maps of sub-cellular compartments in living cells and organoids and enable fast tissue classification with unprecedented biomolecular sensitivity. High acquisition speed will allow the observation of intra and inter-cellular dynamic changes by time-lapse imaging. 

The CRIMSON project, starting 1 December 2020, lasting 42 months and with a budget exceeding 5M€, will also simulate future in-vivo studies and demonstrate the capability to image inside the body, realizing an innovative endoscope and applying it to ex-vivo thick tissue samples. The results have potentially profound societal impacts, improving patients' quality of life and reducing public healthcare costs.

A multidisciplinary team of world-leading organizations with vertical integration of all required skills composes the consortium, coordinated by Politecnico di Milano (Italy). Three research centers (Politecnico di Milano - Italy, Leibniz Institute of Photonic Technology e.V - Germany and Centre National de la Recherche Scientifique - France), with long-standing expertise in photonics, spectroscopy and nonlinear microscopy, will develop the technology. Three biomedical partners (Istituto Nazionale Tumori - Italy, Institut National de la Santé et de la Recherche Médicale - France and Jena University Hospital - Germany) will validate the imaging system on open biological questions related to cancer, as paradigmatic examples of the complexity and heterogeneity of cellular diseases.

Source: Politecnico di Milano


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