Noninvasive Optical Sensors Provide Real-Time Brain Monitoring After Stroke

The researchers developed an optical monitoring system that can be quickly and easily used in the Emergency Department. Using forehead sensors to emit and detect laser light, the new system could reveal early signs of neurological complications after stroke.

Image source: OSA

By: Raquel Delgado-Mederos, Hospital de la Santa Creu i Sant Pau.

Spectroscopy

“The potential impact of this new approach is quite significant since stroke is a leading cause of long-term disability in adults worldwide,” said Delgado-Mederos. “The efficacy of the treatment depends on achieving a rapid restoration of blood flow to the affected part of the brain.”
 
Continuous blood flow measurements
Currently, most clinicians assess blood flow in the brain using measurements taken at single time points with magnetic resonance or computed tomography. These measurements are usually performed at the time of emergency department admission to help guide a doctor’s treatment decisions. Although a method called Transcranial Doppler can perform continuous monitoring, it only measures blood flow in large vessels and doctors must undergo special training to learn how to use it and interpret the results.
 
“Our optical monitoring approach provides a continuous measure of blood flow in the brain’s microvessels, which directly provide blood to the brain tissue,” said Delgado-Mederos. “Also, the system we created is portable and suitable for continuous measurement of cerebral blood flow at the bedside of the patient, without the need for technical expertise.”
 
The optical monitoring technique is based on diffuse correlation spectroscopy (DCS), which determines blood flow by analyzing fluctuating dark and bright spots, or speckles, produced by laser light traveling through the tissue, including the blood vessels. Combining DCS with near-infrared spectroscopy (NIRS), adds information about the amount of blood in the brain tissue and how much oxygen it carries.
 
The combined DCS/NIRS approach was developed by the paper’s coauthor Turgut Durduran and colleagues at the University of Pennsylvania in the 1990s. Later, at ICFO - the Institute of Photonic Sciences, Barcelona, Spain, Durduran’s group developed user-friendly devices that have allowed the technology to be used as a research tool in hospitals and health care centers around the world.

Creating a system for clinical use
Bringing what was previously a research instrument into the challenging clinical setting of the Emergency department required the researchers to adapt the system for very fast implementation. The compact and user-friendly DCS/NIRS system they developed consists of two optical probes placed on the patient’s forehead. These probes contain custom-built fiber optics to deliver light from an infrared laser, which can travel through the skin and skull to reach the outermost layers of brain. Part of this light scatters back to the surface where it is detected by the optical fibers and used to gauge blood flow and blood oxygenation in the small vessels in the brain.
 
They tested the optical monitoring system on five patients admitted into the emergency department with an acute ischemic stroke and who were treated with tissue plasminogen activator, a drug that dissolves the clot to improve blood flow. They used the system while the treatment was administered and then followed its effect on blood flow and oxygenation.
 
“With optical monitoring, we detected the increase in cerebral blood flow and oxygenation caused by the treatment,” said Delgado-Mederos. “The increased blood flow detected with the new system correlated with the opening of the blocked artery seen using Transcranial Doppler and with improvements in neurological deficits.” 
 
The new study showed that it is feasible to use DCS/NIRS optical monitoring to assess blood flow and oxygenation in the brain after a stroke. The researchers plan to replicate the study with more patients at various clinical centers and under different scenarios to better understand the technique’s performance. They also plan to develop user-friendly software and probes to facilitate large-scale implementation of the system in fast-paced clinical environments. Spin-off companies, including one from ICFO, are also working to commercializing the technology and to raise funds for clinical trials.
 
Related journal article: R. Delgado-Mederos, C. Gregori-Pla, P. Zirak, I. Blanco, L. Dinia, R. Marín, T. Durduran, J. Martí-Fàfregas, “Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke,” Biomed. Opt. Express, Volume 9, Issue 3, 1262-1271 (2018)

DOI: 10.1364/BOE.9.001262

Source: The Optical Society