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Researchers developed an optical method to detect cyclosporine level in biological fluids.

10 Jul | By Biophotonics.World
Researchers developed an optical method to detect cyclosporine level in biological fluids.
Image source: reproduced with permission from Wiley and Sons

Researchers from the Gdańsk University of Technology, Medical University of Gdańsk and Warsaw University of Life Sciences, Marcin Marzejon, Monika Kosowska, Daria Majchrowicz, Barbara Bułło‐Piontecka, Michał Wąsowicz, and Malgorzata Szczerska, have developed a spectroscopic method of detecting cyclosporine levels in biological fluids. In the Journal of Biophotonics, the researchers detail the solution.

Cyclosporine is one of the medicines which is applied before and after the transplantation of organs. Every year over 100,000 solid-organ transplantations are performed worldwide. Cyclosporine is also widely used in medicine and veterinary during the treatment of many immunological diseases, as well as other health issues, for instance, rheumatoid arthritis or dermatological diseases.

The level of this medicine in the patient’s body can be easily changed in the appearance of other drugs or hormonal changes. Moreover, proper determination of cyclosporine level in the body can be made only in a specific time after drug administration. We also need to draw attention to a very narrow therapeutic index, individual for each patient – when a dose is too low it won’t have a desired medical effect while too high may be harmful. Therefore, the information on the level of cyclosporine in the biological fluids of the patient is crucial for the success of the treatment. 

However, until now, the examination of cyclosporine level in body fluids as blood or urine was restricted only to the laboratory investigation which is costly and requires specialized personnel. The investigation can be done only in specialized laboratories, whose number is limited even in developed countries. Moreover, the control measurement of the cyclosporine level in the patient’s fluids was limited to be made once a month or even less frequently. 

From the medical point of view, such a frequency of control can be inadequate to optimize the treatment. Ideally, the patients during therapy should haveaccessto the equipment similar to those designed for the diabetes. 

The development of a spectroscopic method allows for identifying the cyclosporine level in biological fluids. It was tested with the use of blood plasma and hemoglobin. The elaborated method is easy to use and can be applied in point-of-care sensors which will help to control the level of cyclosporine in the every-day life of the patient, making treatment more successful.  

 

Author: Malgorzata Szczerska 

Related journal article: https://doi.org/10.1002/jbio.201800273



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